EP-1233: Model-based prediction of rectal toxicity reduction in prostate cancer IMRT with hydrogel rectum spacer
نویسندگان
چکیده
منابع مشابه
Prostate IMRT: Two-dimensional model of rectal NTCP employing the variability of rectal motion and rectum wall thickness
Background: In order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (NTCP), we consider the fractional dependence of the NTCP on the wall thickness (tW) and rectal displacement (RM). Materials and Methods: The two-dimensional NTCP model (NTCP2D) was developed using radiotherapy plans of ten randomly selected patients with prostat...
متن کاملMinimal Rectal Toxicity in the Setting of Comorbid Crohn’s Disease Following Prostate Cancer Radiotherapy with a Hydrogel Rectal Spacer
We present one of the first cases of a prostate cancer (PCa) patient with inflammatory bowel disease (IBD) treated with intensity-modulated radiotherapy (IMRT) and a hydrogel rectal spacer. A 73-year-old male with a past medical history significant for Crohn's disease (CD) and the recent diagnosis of T1cN0M0 high-risk PCa was referred for definitive radiotherapy. Given the patient's history of ...
متن کاملEffect of a prostate-rectum hydrogel spacer on reducing acute radiation proctitis: A single center experience
Gastrointestinal (GI) and genitourinary (GU) toxicity was assessed during and after conventional IMRT in 21 low to intermediate risk cancer patients that had received an absorbable hydrogel spacer between the prostate and the rectum. The transperineal hydrogel injection resulted in the creation of 11.5 mm space between the prostate and rectum; space that was not decreased throughout radiotherap...
متن کاملprostate imrt: two-dimensional model of rectal ntcp employing the variability of rectal motion and rectum wall thickness
background: in order to improve the evaluation of possible rectal toxicity based on the rectal normal tissue complication probability (ntcp), we consider the fractional dependence of the ntcp on the wall thickness (tw) and rectal displacement (rm). materials and methods: the two-dimensional ntcp model (ntcp2d) was developed using radiotherapy plans of ten randomly selected patients with prostat...
متن کاملHydrogel spacer distribution within the perirectal space in patients undergoing radiotherapy for prostate cancer: Impact of spacer symmetry on rectal dose reduction and the clinical consequences of hydrogel infiltration into the rectal wall.
PURPOSE Hydrogel prostate-rectum spacers, biomaterials placed between the prostate and rectum, continue to gain interest as a method to reduce or limit rectal dose during dose escalated prostate cancer radiation therapy. Because the spacer is initially injected into the perirectal space as a liquid, the final distribution can vary. The purpose of this study was to evaluate hydrogel spacer (Spac...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2015
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)41225-3